An enantiomer of (±)-atenolol
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Enantiomer(s)
17250(±)-Atenolol
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(+)-Atenolol

Item No. 18623

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneacetamide
CAS Number
56715-13-0
Synonyms
  • (R)-Atenolol
Molecular Formula
C14H22N2O3
Formula Weight
266.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 15 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
226, 276 nm
SMILES
NC(CC1=CC=C(OC[C@H](O)CNC(C)C)C=C1)=O
InChi Code
InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)/t12-/m1/s1
InChi Key
METKIMKYRPQLGS-GFCCVEGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    (+)-Atenolol is an enantiomer of the β1-adrenergic receptor (β1-AR) antagonist (±)-atenolol (Item No. 17250).1 (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (Ki = 8.61 µM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stoschitzky, K., Egginger, G., Zernig, G., et al. Stereoselective features of (R)- and (S)-atenolol: Clinical pharmacological, pharmacokinetic, and radioligand binding studies. Chirality 5(1), 15-19 (1993).

    2. Richer, C., Boissier, J.R., and Giudicelli, J.F. Chronic atenolol treatment and hypertension development in spontaneously hypertensive rats. Eur. J. Pharmacol. 47(4), 393-400 (1978).

    3. Pearson, A.A., Gaffney, T.E., Walle, T., et al. A stereoselective central hypotensive action of atenolol. J. Pharmacol. Exp. Ther. 250(3), 759-763 (1989).