A β1-AR antagonist
Related Products
Analytical Standard(s)
26284Atenolol
Enantiomer(s)
18623(+)-Atenolol
Labeled Version(s)
30018(±)-Atenolol-d7
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(±)-Atenolol

Item No. 17250

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneacetamide
CAS Number
29122-68-7
Synonyms
  • ​(R,S)-Atenolol
  • Duraatenol
  • ICI 66082
Molecular Formula
C14H22N2O3
Formula Weight
266.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 15 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
227, 277, 283 nm
SMILES
NC(CC1=CC=C(OCC(O)CNC(C)C)C=C1)=O
InChi Code
InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
InChi Key
METKIMKYRPQLGS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    10 g

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    Product Description

    (±)-Atenolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 1.14 µM).1 It is selective for β1-ARs over β2-ARs (Ki = 48.7 µM). (±)-Atenolol (200 mg/kg per day) delays the onset of hypertension in spontaneously hypertensive rats.2 Formulations containing atenolol have been used in the treatment of high blood pressure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Golf, S., Bjornerheim, R., Erichsen, A., et al. Relative selectivity of different β-adrenoceptor antagonists for human heart β1- and β2-receptor subtypes assayed by a radioligand binding technique. Scand. J. Clin. Lab. Invest. 47(7), 719-723 (1987).

    2. Richer, C., Boissier, J.R., and Giudicelli, J.F. Chronic atenolol treatment and hypertension development in spontaneously hypertensive rats. Eur. J. Pharmacol. 47(4), 393-400 (1978).