A hepatoprotective antioxidant
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Gomisin C

Item No. 18643

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5S,6S,7S,13aS)-5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole-5,6-diol 5-benzoate
CAS Number
58546-56-8
Synonyms
  • Schisantherin A
Molecular Formula
C30H32O9
Formula Weight
536.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 10 mg/mLDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mLEthanol: 5 mg/mL
λmax
222 nm
SMILES
COC(C(OC)=C1OC)=CC2=C1C(C(OC)=C(OCO3)C3=C4)=C4C[C@H](C)[C@](C)(O)[C@H]2OC(C5=CC=CC=C5)=O
InChi Code
InChI=1S/C30H32O9/c1-16-12-18-13-21-25(38-15-37-21)26(35-5)22(18)23-19(14-20(33-3)24(34-4)27(23)36-6)28(30(16,2)32)39-29(31)17-10-8-7-9-11-17/h7-11,13-14,16,28,32H,12,15H2,1-6H3/t16-,28-,30-/m0/s1
InChi Key
UFCGDBKFOKKVAC-DSASHONVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    Gomisin C, a lignan first isolated from the fruits of S. chinensis, scavenges oxygen radicals and reduces the production of reactive oxygen species by inhibiting neutrophil activity.1 It has been shown to attenuate respiratory burst in rat peripheral neutrophils via suppression of NADPH oxidase (39% inhibition at 30 µg/ml) and inhibition of cytosolic calcium release from intracellular stores (36% inhibition at 50 µg/ml).2 Gomisin C can induce liver microsomal cytochrome P450, thus facilitating the clearance of xenobiotics and protecting against hepatotoxicity in rodent models of liver injury.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, T.J., Liu, G.T., Li, X.J., et al. Detection of free radical scavenging activity of schisanhenol by electron spin resonance. Acta Pharmacol. Sin. 11(6), 534-539 (1990).

    2. Wang, J.P., Raung, S.L., Hsu, M.f., et al. Inhibition by gomisin C (a lignan from Schizandra chinensis) of the respiratory burst of rat neutrophils. Br. J. Pharmacol. 113(3), 945-953 (1994).

    3. Li, X.Y. Bioactivity of neolignans from fructus Schizandrae. Mem. Inst. Oswaldo Cruz 86 Suppl 2, 31-37 (1991).