A flavanone rutinoside with diverse biological activities
Related Products
Isomer(s)
23028Neohesperidin
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Hesperidin

Item No. 18646

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-(2S)-4-H-1-benzopyran-4-one
CAS Number
520-26-3
Synonyms
  • Cirantin
  • Hesperetin-7-β-rutinoside
  • Hesperidoside
  • NSC 44184
Molecular Formula
C28H34O15
Formula Weight
610.6
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.5 mg/ml
λmax
283 nm
SMILES
O=C1C2=C(O)C=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4)O3)C=C2O[C@H](C5=CC=C(OC)C(O)=C5)C1
InChi Code
InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
InChi Key
QUQPHWDTPGMPEX-QJBIFVCTSA-N
Origin
Plant/Citrus aurantium L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 g

    $36

    Add

    50 g

    $63

    Add

    100 g

    $96

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Hesperidin is a flavanone rutinoside that has been found in C. aurantium and has diverse biological activities.1,2,3,4,5,6 It reduces the formation of advanced glycation end products (AGEs) in a cell-free assay when used at a concentration of 1 mM.2 Hesperidin (10 nM) reduces NETosis induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in DMSO-differentiated HL-60 neutrophil-like cells.3 It decreases LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) and nitric oxide (NO) in RAW 264.7 cells when used at a concentration of 30 µM.4 Dietary administration of hesperidin (0.5 g/kg) prevents the formation of tongue neoplasms induced by 4-nitroquinoline 1-oxide (4-NDQ; Item No. 42994) in rats.5 It increases femoral bone mineral density in ovariectomized rats.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mizelle, J.W., Dunlap, W.J., Hagen, R.E., et al. Isolation and identification of some flavanone rutinosides of the grapefruit. Anal. Biochem. 12(2), 316-324 (1965).

    2. Li, D., Mitsuhashi, S., and Ubukata, M. Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation. Pharm. Biol. 50(12), 1531-1535 (2012).

    3. Juanlu, C., Chen, L., Sung, C.-J., et al. Phytochemicals as potential inhibitors of NETosis: Implications for immunothrombosis and chronic disease management. BMC Complement Med. Ther. (2026).

    4. Sakata, K., Hirose, Y., Qiao, Z., et al. Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. Cancer Lett. 199, 139-145 (2003).

    5. Tanaka, T., Makita, H., Ohnishi, M., et al. Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: Comparison with the protective effect of β-carotene. Cancer Res. 54, 4653-4659 (1994).

    6. Habauzit, V., Nielsen, I.-L., Gil-Izquierdo, A., et al. Increased bioavailability of hesperetin-7-glucoside compared with hesperidin results in more efficient prevention of bone loss in adult ovariectomised rats. Br. J. Nutr. 102(7), 976-984 (2009).