A carcinogen
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4-NDQ

Item No. 42994

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-nitroquinoline 1-oxide
CAS Number
56-57-5
Synonyms
  • Nitrochin
  • 4-Nitroquinoline N-oxide
  • 4-NQO
  • NSC 19645
Molecular Formula
C9H6N2O3
Formula Weight
190.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=[N]1=CC=C(C2=C1C=CC=C2)[N+]([O-])=O
InChi Code
InChI=1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H
InChi Key
YHQDZJICGQWFHK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    4-NDQ is a carcinogen.1 It forms adducts with adenine and guanine, which can be removed by base excision repair, in E. coli DNA. 4-NDQ (100 µg/ml in the drinking water) induces tongue cancer in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ikenaga, M., Ichikawa-Ryo, H., and Kondo, S. The major cause of inactivation and mutation by 4-nitroquinoline 1-oxide in Escherichia coli: Excisable 4NQO-purine adducts. J. Mol. Biol. 92(2), 341-356 (1975).

    2. Tang, X.-H., Knudsen, B., Bemis, D., et al. Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice. Clin. Cancer Res. 10(Pt 1), 301-313 (2004).