A selective inhibitor of Cdk1 and Cdk5
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Cdk1/5 Inhibitor

Item No. 18740

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-pyrazolo[3,4-b]quinoxalin-3-amine
CAS Number
40254-90-8
Synonyms
  • Cyclin-dependent kinase 1/5 Inhibitor
  • NSC 693868
Molecular Formula
C9H7N5
Formula Weight
185.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
254, 334 nm
SMILES
NC1=NNC2=NC3=C(N=C21)C=CC=C3
InChi Code
InChI=1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14)
InChi Key
DWHVZCLBMTZRQM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $132

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    10 mg

    $238

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    Product Description

    Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC50s = 600 and 400 nM, respectively).1 It less potently inhibits GSK3β (IC50 = 1 µM) and does not block Cdc25 activity.1 This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ortega, M.A., Montoya, M.E., Zarranz, B., et al. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg. Med. Chem. 10(7), 2177-2184 (2002).

    2. Chen, S., Xu, Y., Yuan, X., et al. Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1. Proc. Natl. Acad. Sci. USA 103(43), 15969-15974 (2006).

    3. Nguyen, T.K., and Grant, S. Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism. Mol. Cancer Ther. 13(3), 662-674 (2014).

    4. Topanurak, S., Ferraris, J.D., Li, J., et al. High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase. Proc. Natl. Acad. Sci. USA 110(18), 7482-7487 (2013).