A bronchodilator
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Doxofylline

Item No. 18746

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
CAS Number
69975-86-6
Synonyms
  • ABC 12/3
  • 2-(7'-Theophyllinemethyl)-1,3-dioxolane
Molecular Formula
C11H14N4O4
Formula Weight
266.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 0.5 mg/ml
λmax
273 nm
SMILES
CN(C(N1C)=O)C2=C(N(CC3OCCO3)C=N2)C1=O
InChi Code
InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3
InChi Key
HWXIGFIVGWUZAO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 g

    $36

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    5 g

    $153

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    10 g

    $268

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    25 g

    $420

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    Cayman Chemical
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    Product Description

    Doxofylline is a methylxanthine bronchodilator.1 It inhibits phosphodiesterase 2A1 (PDE2A1) and is an adenosine A2A receptor antagonist (IC50s = 0.74 and 0.9 mM, respectively).2 Doxofylline (10 µM) reduces superoxide production induced by LPS or PMA (Item No. 10008014) in isolated human monocytes.3 It delays platelet-activating factor-induced bronchoconstriction in isolated guinea pig lungs when used at concentrations ranging from 0.28 to 1.5 mM. Doxofylline (1 mg/kg) inhibits LPS-induced neutrophil recruitment to the lungs and IL-6 and TNF-α release into bronchoalveolar fluid (BALF) in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Franzone, J.S., Cirillo, R., and Biffignandi, P. Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF. Eur. J. Pharmacol. 165(2-3), 269-277 (1989).

    2. van Mastbergen, J., Jolas, T., Allegra, L., et al. The mechanism of action of doxofylline is unrelated to HDAC inhibition, PDE inhibition or adenosine receptor antagonism. Pulm. Pharmacol. Ther. 25(1), 55-61 (2012).

    3. Talmon, M., Massara, E., Brunini, C., et al. Comparison of anti-inflammatory mechanisms between doxofylline and theophylline in human monocytes. Pulm. Pharmacol. Ther. 59, 101851 (2019).

    4. Riffo-Vasquez, Y., Man, F., and Page, C.P. Doxofylline, a novofylline inhibits lung inflammation induced by lipopolysacharide in the mouse. Pulm. Pharmacol. Ther. 27(2), 170-178 (2014).