Pricing updated 2019-07-18. Prices are subject to change without notice.
CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM).1 It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.2 Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression.2 It reduces tumor growth in COLO 205 human colon cancer xenografts after oral dosing (70 mg/kg bid) and in Wnt-dependent tumors.1,2
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Mallinger, A., Crumpler, S., Pichowicz, M., et al. Discovery of potent, orally bioavailable, small-
2. Dale, T., Clarke, P.A., Esdar, C., et al. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease Nat. Chem. Biol. 11(12), 973-980 (2015).