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CCT251545

Item № 18761
CAS № 1661839-45-7
Purity ≥95%
product image
                (CAS 1661839-45-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $37.00 0.00
     5 mg $148.00 0.00
     10 mg $259.00 0.00

Pricing updated 2019-04-24. Prices are subject to change without notice.

Description

CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM).1 It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.2 Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression.2 It reduces tumor growth in COLO 205 human colon cancer xenografts after oral dosing (70 mg/kg bid) and in Wnt-dependent tumors.1,2

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Technical Information
Formal Name
8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one
CAS Number
1661839-45-7
Molecular Formula
C23H24ClN5O
Formula Weight
421.9
Purity
≥95%
Formulation
A crystalline solid
λmax
274 nm
SMILES
O=C(NCC1)C1(CC2)CCN2C3=C(C4=CC=C(C5=CN(C)N=C5)C=C4)C=NC=C3Cl
InChI Code
InChI=1S/C23H24ClN5O/c1-28-15-18(12-27-28)16-2-4-17(5-3-16)19-13-25-14-20(24)21(19)29-10-7-23(8-11-29)6-9-26-22(23)30/h2-5,12-15H,6-11H2,1H3,(H,26,30)
InChI Key
LBFYQISQYCGDDW-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Mallinger, A., Crumpler, S., Pichowicz, M., et al. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen J. Med. Chem. 58(4), 1717-1735 (2015).

2. Dale, T., Clarke, P.A., Esdar, C., et al. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease Nat. Chem. Biol. 11(12), 973-980 (2015).

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