A selective antagonist of EBI2 (GPR183)
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NIBR189

Item No. 18792

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2E-propen-1-one
CAS Number
1599432-08-2
Molecular Formula
C21H21BrN2O3
Formula Weight
429.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMF:PBS (pH 7.2) (1:8): 0.1 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/ml
λmax
221, 282 nm
SMILES
BrC1=CC=C(/C=C/C(N2CCN(C(C3=CC=C(OC)C=C3)=O)CC2)=O)C=C1
InChi Code
InChI=1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H,12-15H2,1H3/b11-4+
InChi Key
OFHXXBRBGWUOHR-NYYWCZLTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    NIBR189 is an antagonist of EBI2 (IC50s = 11 and 15 nM for human and mouse receptors, respectively).1 It is selective for EBI2 over a panel of other receptors, enzymes, and transporters. NIBR189 blocks the oxysterol-induced migration of U937 monocytic cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gessier, F., Preuss, I., Yin, H., et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J. Med. Chem. 57, 3358-3368 (2014).