A cell-permeable inhibitor of Cdk1 and Cdk2
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Cdk1/2 Inhibitor III

Item No. 18859

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-amino-3-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
CAS Number
443798-47-8
Synonyms
  • Cyclin-dependent kinase 1/2 Inhibitor III
Molecular Formula
C15H13F2N7O2S2
Formula Weight
425.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 0.2 mg/mLDMSO: 1.4 mg/mL
SMILES
NC1=NC(NC2=CC=C(S(N)(=O)=O)C=C2)=NN1C(NC3=C(F)C=CC=C3F)=S
InChi Code
InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
InChi Key
ARIOBGGRZJITQX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $107

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    5 mg

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    10 mg

    $636

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    Product Description

    Cdk1/2 Inhibitor III is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50s = 0.6 and 0.5 nM, respectively).1 It less potently inhibits CDC2-like kinases 1 and 3, VEGFR2, and GSK-3β (IC50s = 8.9, 29, 32, and 140 nM, respectively) and is without effect against a panel of other kinases.1,2 Cdk1/2 Inhibitor III blocks the growth of several cancer cell lines (IC50 values range from 20 to 92 nM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, R., Connolly, P.J., Huang, S., et al. 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: Synthesis and evaluation of biological activities. J. Med. Chem. 48(13), 4208-4211 (2005).

    2. Fedorov, O., Huber, K., Eisenreich, A., et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem. Biol. 18(1), 67-76 (2011).