A histamine H2 receptor antagonist
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Product Categories

Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

Nizatidine

Item No. 18861

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N'-[2-[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N-methyl-2-nitro-1,1-ethenediamine
CAS Number
76963-41-2
Synonyms
  • LY139037
Molecular Formula
C12H21N5O2S2
Formula Weight
331.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
241, 326 nm
SMILES
CN/C(NCCSCC1=CSC(CN(C)C)=N1)=C\[N+]([O-])=O
InChi Code
InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+
InChi Key
SGXXNSQHWDMGGP-IZZDOVSWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    10 g

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    25 g

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    Product Description

    Nizatidine is a histamine H2 receptor antagonist that decreases gastric acid secretion (ED50 = 0.9 µM in isolated gastric mucosa of bullfrog and ED50s = 1.383 and 0.08 μmol/kg in rats and dogs, respectively).1 Its gastroprotective activity has been exploited in clinical studies of various gastric acid disorders.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, T.M., Evans, D.C., Warrick, M.W., et al. Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs. J. Pharmacol. Exp. Ther. 239(2), 406-410 (1986).

    2. Feldman, M., and Burton, M.E. Histamine2-receptor antagonists. Standard therapy for acid-peptic diseases. (First of two parts). N. Engl. J. Med. 323(24), 1672-1680 (1990).

    3. Tuskey, A., and Peura, D. The use of H2 antagonists in treating and preventing NSAID-induced mucosal damage. Arthritis Res. Ther. 15(Suppl 3), 1-7 (2013).