A centrally acting muscle relaxant
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Chlorzoxazone

Item No. 18869

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-2(3H)-benzoxazolone
CAS Number
95-25-0
Synonyms
  • NSC 26189
Molecular Formula
C7H4ClNO2
Formula Weight
169.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
ClC1=CC=C(OC(N2)=O)C2=C1
InChi Code
InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
InChi Key
TZFWDZFKRBELIQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $41

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    50 g

    $69

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    100 g

    $110

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    250 g

    $204

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    Product Description

    Chlorzoxazone is a centrally acting muscle relaxant and activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1, respectively).1,2 In vivo, chlorzoxazone (10 mg/kg) decreases alcohol but not water intake in a dose-dependent manner and reduces the propensity for rapid initial alcohol intake in rats with intermittent, but not continuous, access to alcohol.3 Formulations containing chlorzoxazone have been used in the treatment of pain and stiffness caused by muscle spasm. This product is also available as an analytical reference standard (Item No. 25826).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pedarzani, P., and Stocker, M. Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain. Cell. Mol. Life Sci. 65(20), 3196-3217 (2008).

    2. Gao, Z., Todorov, B., Barrett, C.F., et al. Cerebellar ataxia by enhanced Cav2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1aS218L mutant mice. J. Neurosci. 32(44), 15533-15546 (2012).

    3. Hopf, F.W., Simms, J.A., Chang, S.-J., et al. Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol. Psychiatry 69(7), 618-624 (2011).