A dopamine D2 receptor antagonist
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Labeled Version(s)
30152Domperidone-d6
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Domperidone

Item No. 18875

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
CAS Number
57808-66-9
Synonyms
  • KW 5338
  • NSC 299589
Molecular Formula
C22H24ClN5O2
Formula Weight
425.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
209, 287 nm
SMILES
O=C(NC1=C2C=CC=C1)N2CCCN3CCC(N4C(C=CC(Cl)=C5)=C5NC4=O)CC3
InChi Code
InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
InChi Key
FGXWKSZFVQUSTL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 mg

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    50 mg

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    Product Description

    Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor).1,2 It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM).1 Domperidone (0.5-5 μg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and has no effect on dopamine-induced vasodilation in the renal vascular bed in dogs when administered at doses up to 5 mg/kg, indicating a lack of activity at dopamine D1 receptors.2 Domperidone (0.5 mg/kg) prevents dopamine-induced decreases in gastric antral motility induced by pentagastrin (Item No. 28546) in dogs.3 It inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.).4 Domperidone also increases serum levels of prolactin in male rats.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sokoloff, P., Giros, B., Martres, M.P., et al. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 137(6289), 146-151 (1990).

    2. Kohli, J.D., Glock, D., and Goldberg, L.I. Selective DA2 versus DA1 antagonist activity of domperidone in the periphery. Eur. J. Pharmacol. 89(1-2), 137-141 (1983).

    3. Bech, K., Hovendal, C.P., and Andersen, D. Effect of dopamine on pentagastrin-stimulated gastric antral motility in dogs with gastric fistula. Scand. J. Gastroenterol. 17(1), 103-107 (1982).

    4. Niemegeers, C.J.E. Antiemetic specificity of dopamine antagonists. Psychopharmacology (Berl.) 78(3), 210-213 (1982).

    5. Meltzer, H.Y., Simonovic, M., and So, R. Effects of a series of substituted benzamides on rat prolactin secretion and 3H-spiperone binding to bovine anterior pituitary membranes. Life Sci. 32(25), 2877-2886 (1983).