A benzimidazole anthelmintic
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Labeled Version(s)
34011Triclabendazole-13C-d3
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Triclabendazole

Item No. 18883

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole
CAS Number
68786-66-3
Synonyms
  • TCBZ
Molecular Formula
C14H9Cl3N2OS
Formula Weight
359.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10mM
λmax
222, 254, 306 nm
SMILES
ClC1=CC=CC(OC2=C(Cl)C=C(NC(SC)=N3)C3=C2)=C1Cl
InChi Code
InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)
InChi Key
NQPDXQQQCQDHHW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $41

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    1 g

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    5 g

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    Cayman Chemical
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    Product Description

    Triclabendazole is a benzimidazole anthelmintic.1 It eliminates both immature and adult flukes in a sheep model of F. hepatica infection when administered at a dose of 10 mg/kg.2 Triclabendazole (5 µM) also protects against glucose- or α-synuclein-induced apoptosis in S. cerevisiae via inhibition of adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A (PKA) nutrient sensing pathway.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shrifi, Y., Farahnak, A., Golestani, A., et al. Triclabendazole effect on protease enzyme activity in the excretory- secretory products of Fasciola hepatica in vitro. Iran. J. Parasitol. 9(1), 107-113 (2014).

    2. Smeal, M.G., and Hall, C.A. The activity of triclabendazole against immature and adult Fasciola hepatica infections in sheep. Aust. Vet. J. 60(11), 329-331 (1983).

    3. Lee, Y.J., Burlet, E., Wang, S., et al. Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound. Biochem. Biophys. Res. Commun. 414(1), 205-208 (2011).