An internal standard for the quantification of triclabendazole
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Unlabeled Version(s)
18883Triclabendazole
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Triclabendazole-13C-d3

Item No. 34011

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-5-(2,3-dichlorophenoxy)-2-((methyl-13C-d3)thio)-1H-benzimidazole
CAS Number
2938916-53-9
Synonyms
  • TCBZ-13C-d3
Molecular Formula
C13[13C]H6D3Cl3N2OS
Formula Weight
363.7
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: solubleMethanol: soluble
SMILES
ClC1=CC=CC(OC2=C(Cl)C=C(N=C(S[13C]([2H])([2H])[2H])N3)C3=C2)=C1Cl
InChi Code
InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)/i1+1D3
InChi Key
NQPDXQQQCQDHHW-KQORAOOSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    Triclabendazole-13C-d3 is intended for use as an internal standard for the quantification of triclabendazole (Item No. 18883) by GC- or LC-MS. Triclabendazole is a benzimidazole anthelmintic.1 It eliminates both immature and adult flukes in a sheep model of F. hepatica infection when administered at a dose of 10 mg/kg.2 Triclabendazole (5 µM) also protects against glucose- or α-synuclein-induced apoptosis in S. cerevisiae via inhibition of adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A (PKA) nutrient sensing pathway.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shrifi, Y., Farahnak, A., Golestani, A., et al. Triclabendazole effect on protease enzyme activity in the excretory- secretory products of Fasciola hepatica in vitro. Iran. J. Parasitol. 9(1), 107-113 (2014).

    2. Smeal, M.G., and Hall, C.A. The activity of triclabendazole against immature and adult Fasciola hepatica infections in sheep. Aust. Vet. J. 60(11), 329-331 (1983).

    3. Lee, Y.J., Burlet, E., Wang, S., et al. Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound. Biochem. Biophys. Res. Commun. 414(1), 205-208 (2011).