A selective inhibitor of CK2
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4,5,6,7-Tetrabromobenzimidazole

Item No. 18886

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5,6,7-tetrabromo-1H-benzimidazole
CAS Number
577779-57-8
Synonyms
  • Casein Kinase II Inhibitor XII
  • TBBz
Molecular Formula
C7H2Br4N2
Formula Weight
433.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Soluble
SMILES
BrC1=C2C(N=CN2)=C(Br)C(Br)=C1Br
InChi Code
InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)
InChi Key
LOEIRDBRYBHAJB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $87

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    25 mg

    $207

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    50 mg

    $348

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    Product Description

    4,5,6,7-Tetrabromobenzimidazole is a selective, ATP-competitive inhibitor of CK2 with Ki values ranging from 0.5-1 µM in rat liver, S. cerevisiae, C. tropicalis, and N. crassa.1 It is inactive against PKA and PKC and a relatively weak inhibitor of CK1 (Ki = 54.4-64.2 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zien, P., Bretner, M., Zastapilo, K., et al. Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources. Biochem. Biophys. Res. Commun. 306(1), 129-133 (2003).