A phosphorylated aldohexose with diverse roles
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

D-Mannose-6-Phosphate (sodium salt hydrate)

Item No. 18890

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2R,3R,4S,5S-tetrahydroxy-6-oxohexyl phosphate, disodium salt, hydrate
Synonyms
  • M6P
Molecular Formula
C6H11O9P • 2Na [XH2O]
Formula Weight
304.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O=C[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)COP([O-])([O-])=O.[Na+].[Na+].O
InChi Code
InChI=1S/C6H13O9P.2Na.H2O/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;;;/h1,3-6,8-11H,2H2,(H2,12,13,14);;;1H2/q;2*+1;/p-2/t3-,4-,5-,6-;;;/m1.../s1
InChi Key
AKHAALUPXATQSW-KPGAZFBQSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $59

    Add

    50 mg

    $148

    Add

    100 mg

    $236

    Add

    500 mg

    $738

    Add
    Product Description

    D-Mannose-6-phosphate (M6P) is a phosphorylated aldohexose that has diverse physiological roles. It can be used to produce glucose as an energy source, converted to mannitol to serve as an osmolyte or metabolic store, or directed to the N-glycosylation pathway.1,2 M6P is also a ligand for both cation-dependent and -independent receptors and binds, as part of an N-glycan, to mannose receptor homology domains on other proteins.3,4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharma, V., Ichikawa, M., and Freeze, H.H. Mannose metabolism: More than meets the eye. Biochim. Biophys. Res. Commun. 453(2), 220-228 (2014).

    2. Meena, M., Prasad, V., Zehra, A., et al. Mannitol metabolism during pathogenic fungal-host interactions under stressed conditions. Front. Microbiol. 6, (2015).

    3. Ferlinz, K., Kopal, G., Bernardo, K., et al. Human acid ceramidase. Processing, glycosylation, and lysosomal targeting. The Journal of Biological Chemisty 276(38), 35352-35360 (2001).

    4. Saris, J.J., Derkx, F.H.M., De Bruin, R.J.A., et al. High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin. Am. J. Physiol. Heart Circ. Physiol. 280(4), H1706-H1715 (2001).

    5. D'Alessio, C., and Dahms, N.M. Glucosidase II and MRH-domain containing proteins in the secretory pathway. Curr.Protein Pept.Sci. 16(1), 31-48 (2015).

    6. Hosokawa, N., Kamiya, Y., and Kato, K. The role of MRH domain-containing lectins in ERAD. Glycobiology 20(6), 651-660 (2010).