A TP receptor antagonist and inhibitor of TX synthase
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Pinane Thromboxane A2

Item No. 19020

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5Z)-7-[(1S,2R,3R,5S)-3-[(1E,3S)-3-hydroxy-1-octen-1-yl]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5-heptenoic acid
CAS Number
71111-01-8
Synonyms
  • 15(S)-Pinane Thromboxane A2
  • Pinane TXA2
  • PTA2
Molecular Formula
C24H40O3
Formula Weight
376.6
Purity
≥98%
Formulation
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: >50 mg/mlDMSO: >25 mg/mlEthanol: >100 mg/mlPBS pH 7.2: >100 µg/ml
SMILES
CCCCC[C@H](O)/C=C/[C@H]1C[C@H]2C[C@H](C2(C)C)[C@@H]1C/C=C\CCCC(O)=O
InChi Code
InChI=1S/C24H40O3/c1-4-5-8-11-20(25)15-14-18-16-19-17-22(24(19,2)3)21(18)12-9-6-7-10-13-23(26)27/h6,9,14-15,18-22,25H,4-5,7-8,10-13,16-17H2,1-3H3,(H,26,27)/b9-6-,15-14+/t18-,19-,20-,21+,22-/m0/s1
InChi Key
OHJIHGVLRDHSDV-BNAVIEMTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $83

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    1 mg

    $158

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    5 mg

    $660

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    10 mg

    $1,073

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    Product Description

    Pinane thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of thromboxane synthase.1,2 PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase (ID50 = 50 µM). PTA2 does not affect PGI synthase up to a concentration of 100 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nicolaou, K.C., Magolda, R.L., Smith, J.B., et al. Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation. Proc. Natl. Acad. Sci. USA 76, 2566-2570 (1979).

    2. Schrör, K., Smith, E.F., III, Bickerton, M., et al. Preservation of ischemic myocardium by pinane thromboxane A2. Am. J. Physiol. 238, H87-H92 (1980).