A high-affinity TP receptor antagonist
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I-SAP

Item No. 19021

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5Z)-7-[(1S,2S,3S,5R)-3-[[(4-iodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5-heptenoic acid
CAS Number
133538-58-6
Synonyms
  • Iodophenyl sulfonyl amino pinane Thromboxane A2
  • Iodophenyl sulfonyl amino pinane TXA2
Molecular Formula
C22H30INO4S
Formula Weight
531.4
Purity
≥98%
Formulation
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: >50 mg/ml (from Pinane TXA2)DMSO: >25 mg/ml (from Pinane TXA2)Ethanol: >100 mg/ml (from Pinane TXA2)PBS pH 7.2: >100 µg/ml (from Pinane TXA2)
λmax
249 nm
SMILES
CC1(C)[C@@H]2[C@H](C/C=C\CCCC(O)=O)[C@@H](N([H])S(C3=CC=C(I)C=C3)(=O)=O)C[C@H]1C2
InChi Code
InChI=1S/C22H30INO4S/c1-22(2)15-13-19(22)18(7-5-3-4-6-8-21(25)26)20(14-15)24-29(27,28)17-11-9-16(23)10-12-17/h3,5,9-12,15,18-20,24H,4,6-8,13-14H2,1-2H3,(H,25,26)/b5-3-/t15-,18+,19+,20+/m1/s1
InChi Key
SZNMERGTFJHNSM-JAWYFFTGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $81

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    1 mg

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    Product Description

    I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Naka, M., Mais, D.E., Morinelli, T.A., et al. 7-[(1R,2S,3S,5R)-6,6-Dimethyl-3-(4-iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: A novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors. J. Pharmacol. Exp. Ther. 262, 632-637 (1992).