An Analytical Reference Material
Features
  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Nortriptyline (hydrochloride)

Item No. 19041

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, monohydrochloride
CAS Number
894-71-3
Molecular Formula
C19H21N • HCl
Formula Weight
299.8
Purity
≥98%
Formulation
A neat solid
SMILES
CNCC/C=C1C2=C(C=CC=C2)CCC3=C/1C=CC=C3.Cl
InChi Code
InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
InChi Key
SHAYBENGXDALFF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $24

    Add

    5 mg

    $63

    Add
    Cayman Chemical
    Forensic Lab Guide Wall Posters

    Discover our collection of drug identification, naming, and metabolism posters for your lab. We offer all of our posters at no cost to help support the forensic community.

    REQUEST YOURS
    Product Description

    Nortriptyline (hydrochloride) (Item No. 19041) is an analytical reference material categorized as an antidepressant.1 Nortriptyline is an active metabolite of amitriptyline (Item Nos. 19031 | 19029).2 It decreases immobility time in the forced swim test in rats and has antinociceptive activity in mice.1,3 Nortriptyline decreases nicotine self-administration in rats.4 Formulations containing nortriptyline have been used in the treatment of depression. This product is intended for analytical forensic applications. This product is also available as a general research tool (Item No. 15904).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Petersén, A., Wörtwein, G., Gruber, S.H., et al. Nortriptyline mediates behavioral effects without affecting hippocampal cytogenesis in a genetic rat depression model. Neurosci. Lett. 451(2), 148-151 (2009).

    2. Coutts, R.T., Bach, M.V., and Baker, G.B. Metabolism of amitriptyline with CYP2D6 expressed in a human cell line. Xenobiotica 27(1), 33-47 (1997).

    3. Tavakoli, F., Hejazian, S.H., and Anoosheh, S.M. Antinociceptive activity of nortriptyline through the adrenergic system - an in vivo study in mice. Int. J. Clin. Exp. Physiol. 5(3), 120-122 (2018).

    4. Wing, V.C., and Shoaib, M. Translating the smoking cessation properties of the antidepressant nortriptyline using reinforcing, discriminative and aversive stimulus effects of nicotine in rats. Psychopharmacology (Berl.) 219, 847-857 (2012).