An abundant urinary metabolite of TXB2
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Labeled Version(s)
100095842,3-dinor Thromboxane B2-d9
Parent Compound(s)
19030Thromboxane B2
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2,3-dinor Thromboxane B2

Item No. 19050

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11,15S-trihydroxy-2,3-dinor-thromba-5Z,13E-dien-1-oic acid
CAS Number
63250-09-9
Synonyms
  • 2,3-dinor TXB2
Molecular Formula
C18H30O6
Formula Weight
342.4
Purity
≥95%
Formulation (Request formulation change)
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/ml (from TXB2)DMSO: 25 mg/ml (from TXB2)Ethanol: 100 mg/ml (from TXB2)PBS pH 7.2: 100 mg/ml (from TXB2)
SMILES
O[C@@H]1[C@H](C/C=C\CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)OC(O)C1
InChi Code
InChI=1S/C18H30O6/c1-2-3-4-7-13(19)10-11-16-14(8-5-6-9-17(21)22)15(20)12-18(23)24-16/h5-6,10-11,13-16,18-20,23H,2-4,7-9,12H2,1H3,(H,21,22)/b6-5-,11-10+/t13-,14-,15-,16+,18?/m0/s1
InChi Key
RJHNVFKNIJQTQF-LMIBIYGPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $148

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    50 µg

    $266

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    100 µg

    $472

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    Product Description

    Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.1 2,3-dinor TXB2 is an abundant urinary metabolite of TXB2 and can be used as a marker for in vivo TXA2 synthesis.1,2,3 In healthy male volunteers, the median excretion of 2,3-dinor TXB2 is 10.3 ng/hour (138 pg/mg creatine).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim. Biophys. Acta 992(1), 66-70 (1989).

    2. Lawson, J.A., Brash, A.R., Doran, J., et al. Measurement of urinary 2,3-dinor-thromboxane B2 and thromboxane B2 using bonded-phase phenylboronic acid columns and capillary gas chromatography-negative-ion chemical ionization mass spectrometry. Anal. Biochem. 150, 463-470 (1985).

    3. Lawson, J.A., Patrono, C., Ciabattoni, G., et al. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation. Anal. Biochem. 155(1), 198-205 (1986).