A selective RARγ agonist
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CD1530

Item No. 19062

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(6-hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)-benzoic acid
CAS Number
107430-66-0
Molecular Formula
C27H26O3
Formula Weight
398.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
50 mM in 1 eq. NaOH: Soluble
λmax
232, 277, 325 nm
SMILES
OC(C1=CC=C(C2=CC(C=C(C34C[C@H](C[C@@H](C5)C4)C[C@H]5C3)C(O)=C6)=C6C=C2)C=C1)=O
InChi Code
InChI=1S/C27H26O3/c28-25-12-22-6-5-21(19-1-3-20(4-2-19)26(29)30)10-23(22)11-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)/t16-,17+,18-,27?
InChi Key
VCQGNUWOMLYNNG-PSAKPEQJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    CD1530 is a selective retinoic acid receptor (RARγ) agonist (Kds = 150, 1,500, and 2,750 nM for RARγ, RARβ, and RARα receptors, respectively).1 It demonstrates transcriptional activity at RARγ with an AC50 value of 1.8 nM.1 It has been used in combination with bexarotene (Item No. 11571), a retinoid X receptor agonist, to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bernard, B.A., Bernardon, J.-M., Delescluse, C., et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ. Biochem. Biophys. Res. Commun. 186(2), 977-983 (1992).

    2. Tang, X.-H., Osei-Sarfo, K., Urvalek, A.M., et al. Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proc. Natl. Acad. Sci. USA 111(24), 8907-8912 (2014).