An inhibitor of haspin and DYRK2
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LDN-192960 (hydrochloride)

Item No. 19089

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(2,7-dimethoxy-9-acridinyl)thio]-1-propanamine, dihydrochloride
CAS Number
2309172-48-1
Molecular Formula
C18H20N2O2S • 2HCl
Formula Weight
401.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
264 nm
SMILES
COC1=CC2=C(SCCCN)C3=CC(OC)=CC=C3N=C2C=C1.Cl.Cl
InChi Code
InChI=1S/C18H20N2O2S.2ClH/c1-21-12-4-6-16-14(10-12)18(23-9-3-8-19)15-11-13(22-2)5-7-17(15)20-16;;/h4-7,10-11H,3,8-9,19H2,1-2H3;2*1H
InChi Key
FNHCUCJBABESJB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $203

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    25 mg

    $451

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    50 mg

    $845

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    Product Description

    LDN-192960 is an inhibitor of haspin protein kinase and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) with IC50 values of 10 and 48 nM, respectively.1 It is selective for haspin and DYRK2 over TRKB, CLK1, DYRK1A, DYRK3, ROS, HIPK1, HIPK2, PIM-1, and PIM-2 kinases (IC50s = 720-91,000 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cuny, G.D., Robin, M., Ulyanova, N.P., et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg. Med. Chem. Lett. 20(12), 3491-3493 (2010).