A fatty acid synthase inhibitor
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UCM05

Item No. 19090

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4,5-trihydr3,4,5-trihydroxy-benzoic acid 1,1'-(1,3-naphthalenediyl) ester
CAS Number
1094451-90-7
Synonyms
  • G28UCM
Molecular Formula
C24H16O10
Formula Weight
464.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: 12 mg/mlEthanol:PBS (pH 7.2) (1:40): 0.02 mg/ml
λmax
223, 288 nm
SMILES
OC1=C(O)C(O)=CC(C(OC2=CC(C=CC=C3)=C3C(OC(C4=CC(O)=C(O)C(O)=C4)=O)=C2)=O)=C1
InChi Code
InChI=1S/C24H16O10/c25-16-6-12(7-17(26)21(16)29)23(31)33-14-5-11-3-1-2-4-15(11)20(10-14)34-24(32)13-8-18(27)22(30)19(28)9-13/h1-10,25-30H
InChi Key
KJCWIWDPTNVWRX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    Product Description

    UCM05 is an inhibitor of fatty acid synthase that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 µM for SK-BR-3 cells).1,2 It does not alter carnitine palmitoyltransferase 1 activity or induce weight loss in mice.1,2 UCM05 can reduce cleavage of poly(ADP-ribose) polymerase, phosphorylation of HER2, Akt, and ERK1/2, and growth of established xenografts in vivo.3 UCM05 also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus, preventing bacterial division.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Puig, T., Turrado, C., Benhamú, B., et al. Novel inhibitors of fatty acid synthase with anticancer activity. Clin. Cancer Res. 15(24), 7608-7615 (2009).

    2. Turrado, C., Puig, T., García-Cárceles, J., et al. New synthetic inhibitors of fatty acid synthase with anticancer activity. J. Med. Chem. 55(11), 5013-5023 (2012).

    3. Puig, T., Aguilar, H., Cufi, S., et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 13(6), (2011).

    4. Ruiz-Avila, L.B., Huecas, S., Artola, M., et al. Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ. ACS Chem. Biol. 8(9), 2072-2083 (2013).