An antagonist of mGluR7
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XAP044

Item No. 19095

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
CAS Number
196928-50-4
Molecular Formula
C15H9IO4
Formula Weight
380.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 10 mg/ml
λmax
236, 250, 299 nm
SMILES
O=C1C2=CC=C(O)C=C2OC=C1OC3=CC=C(I)C=C3
InChi Code
InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
InChi Key
XXZKJJYWINSUMJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $123

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    10 mg

    $227

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    Product Description

    XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM.1 This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gee, C.E., Peterlik, D., Neuhäuser, C., et al. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. The Journal of Biological Chemisty 289(16), 10975-10987 (2014).