An internal standard for the quantification of flavoxate
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Labeled Version(s)
33816Flavoxate-d5
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Flavoxate (hydrochloride)

Item No. 19096

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester, monohydrochloride
CAS Number
3717-88-2
Synonyms
  • NSC 114649
  • Rec 7/0040
Molecular Formula
C24H25NO4 • HCl
Formula Weight
427.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 1 mg/ml
λmax
241, 289, 316 nm
SMILES
CC1=C(C2=CC=CC=C2)OC3=C(C(OCCN4CCCCC4)=O)C=CC=C3C1=O.Cl
InChi Code
InChI=1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H
InChi Key
XOEVKNFZUQEERE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $93

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    25 mg

    $213

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    50 mg

    $354

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    Product Description

    Flavoxate is an inhibitor of L-type calcium channels and an antimuscarinic agent.1 It induces relaxation of potassium-precontracted isolated human urinary bladder detrusor muscle (IC50 = 2 µM) and reduces contractions induced by the acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) or calcium in isolated rat detrusor strips.1,2 Microinjection of flavoxate (0.68 µg/animal) into the oral pontine reticular nucleus inhibits reflex micturition in decerebrated cats, and intravenous or intracerebroventricular administration reduces isovolumetric rhythmic bladder contractions in rats.2 Formulations containing flavoxate have previously been used in the treatment of frequent or urgent urination, increased nocturnal urination, bladder pain, and urinary incontinence.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tomoda, T., Aishima, M., Takano, N., et al. The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder. Brit. J. Pharmacol. 146(1), 25-32 (2005).

    2. Kimura, Y., Sasaki, Y., Hamada, K., et al. Mechanisms of the suppression of the bladder activity by flavoxate. Int. J. Urol. 3(3), 218-227 (1996).