A CDK inhibitor
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Purvalanol B

Item No. 19115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]-benzoic acid
CAS Number
212844-54-7
Synonyms
  • NG 95
Molecular Formula
C20H25ClN6O3
Formula Weight
432.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2) (1:5): 0.2 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/ml
λmax
210, 222, 284, 329 nm
SMILES
CC(C)N1C2=NC(N[C@H](C(C)C)CO)=NC(NC3=CC(Cl)=C(C(O)=O)C=C3)=C2N=C1
InChi Code
InChI=1S/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1
InChi Key
ZKDXRFMOHZVXSG-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $46

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    5 mg

    $102

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    10 mg

    $134

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    25 mg

    $278

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    Product Description

    Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively).1 It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gray, N.S., Wodicka, L., Thunnissen, A.M.W.H., et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281(5376), 533-538 (1998).

    2. Knockaert, M., Gray, N., Damiens, E., et al. Intracellular targets of cyclin-dependent kinase inhibitors: Identification by affinity chromatography using immobilised inhibitors. Chem. Biol. 7(6), 411-422 (2000).

    3. Bullard, K.M., Broccardo, C., and Keenan, S.M. Effects of cyclin-dependent kinase inhibitor Purvalanol B application on protein expression and developmental progression in intra-erythrocytic Plasmodium falciparum parasites. Malar. J. 14, (2015).