A S1P3 receptor antagonist
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TY 52156

Item No. 19119

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-chlorophenyl)-3,3-dimethyl-2-oxobutanimidic acid, 2-(4-chlorophenyl)hydrazide
CAS Number
934369-14-9
Molecular Formula
C18H19Cl2N3O
Formula Weight
364.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 15 mg/ml
λmax
248, 301, 359 nm
SMILES
CC(C)(C)C(/C(NNC1=CC=C(Cl)C=C1)=N/C2=CC=C(Cl)C=C2)=O
InChi Code
InChI=1S/C18H19Cl2N3O/c1-18(2,3)16(24)17(21-14-8-4-12(19)5-9-14)23-22-15-10-6-13(20)7-11-15/h4-11,22H,1-3H3,(H,21,23)
InChi Key
XONRRGIRSGNWFP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $203

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    25 mg

    $462

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    Product Description

    TY 52156 is a selective sphingosine-1-phosphate receptor 3 (SIP3) antagonist (Ki = 110 nM).1 It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4.1 TY 52156 has been shown to suppress FTY720-induced S1P3 receptor-mediated coronary flow in isolated perfused rat hearts.1 TY 52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murakami, A., Takasugi, H., Ohnuma, S., et al. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: Investigation based on a new S1P3 receptor antagonist. Mol. Pharmacol. 77(4), 704-713 (2016).

    2. Hirata, N., Yamada, S., Shoda, T., et al. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat. Commun. 5:4806, (2014).