A PAR4 antagonist
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ML-354

Item No. 19120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-5-nitro-3-phenyl-1H-indole-2-methanol
CAS Number
89159-60-4
Synonyms
  • VU0099704
Molecular Formula
C16H14N2O3
Formula Weight
282.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/ml
λmax
263, 280 nm
SMILES
CN1C(CO)=C(C2=CC=CC=C2)C3=C1C=CC([N+]([O-])=O)=C3
InChi Code
InChI=1S/C16H14N2O3/c1-17-14-8-7-12(18(20)21)9-13(14)16(15(17)10-19)11-5-3-2-4-6-11/h2-9,19H,10H2,1H3
InChi Key
GNJUKVGDCUKDLF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $161

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    25 mg

    $378

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    Product Description

    ML-354 is an indole-based, proteinase-activated receptor 4 (PAR4) antagonist (IC50 = 140 nM) that exhibits 71-fold selectivity for PAR4 over PAR1 (IC50 = 10 μM) in isolated human platelets.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wen, W., Young, S.E., Duvernay, M.T., et al. Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg. Med. Chem. Lett. 24, 4708-4713 (2014).