A nonpeptide ligand that releases IGF-1 from IGFBP
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NBI 31772

Item No. 19122

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3,4-dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid
CAS Number
374620-70-9
Molecular Formula
C17H11NO7
Formula Weight
341.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 0.14 mg/ml
λmax
258 nm
SMILES
OC1=C(O)C=C(C=C(C(O)=O)N=C2C(C3=CC=C(O)C(O)=C3)=O)C2=C1
InChi Code
InChI=1S/C17H11NO7/c19-11-2-1-7(4-12(11)20)16(23)15-9-6-14(22)13(21)5-8(9)3-10(18-15)17(24)25/h1-6,19-22H,(H,24,25)
InChi Key
ZCMFEWUYBFMLIN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $145

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    10 mg

    $236

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    25 mg

    $502

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    Cayman Chemical
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    Product Description

    NBI 31772 is a nonpeptide ligand that releases insulin-like growth factor-1 (IGF-1) from its binding protein (IGFBP; Kis = 1-24 nM for the six human subtypes of IGFBP).1,2 As the released IGF-1 is biologically active, NBI 31772 is used to assess the role of IGF-1 in cells and animals, including in neuron survival, skeletal muscle regeneration, and glucose homeostasis.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. De Ceuninck, F., Caliez, A., Dassencourt, L., et al. Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes. Arthirits Res. Ther. 6(5), R393-R403 (2004).

    2. Liu, X.-J., Xie, Q.W., Zhu, Y.-F., et al. Identification of a nonpeptide ligand that releases bioactive insulin-like growth factor-I from its binding protein complex. The Journal of Biological Chemisty 276(35), 32419-32422 (2001).

    3. Hollis, E.R., II, Lu, P., Blesch, A., et al. IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury. Exp. Neurol. 215(1), 53-59 (2009).

    4. Schertzer, J.D., Gehrig, S.M., Ryall, J.G., et al. Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. Am. J. Pathol. 171(4), 1180-1188 (2007).

    5. Silha, J.V., and Murphy, L.J. The effects of the insulin-like growth factor-I aptamer, NBI-31772, on glucose homeostasis in the mouse. Can. J. Physiol. Pharmacol. 83(7), 557-563 (2005).