A Nrf2 activator
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NK 252

Item No. 19131

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)-urea
CAS Number
1414963-82-8
Molecular Formula
C13H11N5O3
Formula Weight
285.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 14 mg/ml
λmax
275 nm
SMILES
O=C(NC1=NN=C(C2=CC=CO2)O1)NCC3=CC=CC=N3
InChi Code
InChI=1S/C13H11N5O3/c19-12(15-8-9-4-1-2-6-14-9)16-13-18-17-11(21-13)10-5-3-7-20-10/h1-7H,8H2,(H2,15,16,18,19)
InChi Key
FNSCFQXZZNCDAI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $169

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    25 mg

    $378

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    Cayman Chemical
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    Product Description

    NK 252 is a Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1.1 At 1.36 µM, it is reported to activate the NQO1-antioxidant response element in a luciferase reporter gene assay two-fold above background.1 NK 252 has been shown to downregulate the expression of fibrogenic genes, producing antifibrotic effects in a rat model of non-alcoholic steatohepatitis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimozono, R., Asaoka, Y., Yoshizawa, Y., et al. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol. Pharmacol. 84(1), 62-70 (2013).