A selective p38 MAPK inhibitor
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SB 239063

Item No. 19142

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-cyclohexanol
CAS Number
193551-21-2
Molecular Formula
C20H21FN4O2
Formula Weight
368.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 16 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/mlEthanol: 0.25 mg/ml
λmax
232, 268, 317 nm
SMILES
O[C@@H](CC1)CC[C@H]1N2C(C3=CC=NC(OC)=N3)=C(C4=CC=C(F)C=C4)N=C2
InChi Code
InChI=1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3/t15-,16-
InChi Key
ZQUSFAUAYSEREK-WKILWMFISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $41

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    1 mg

    $75

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    5 mg

    $140

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    Product Description

    SB 239063 is a selective p38 MAPK inhibitor (IC50 = 44 nM for recombinant purified p38α).1 It displays greater than 220-fold selectivity for p38 MAPK over ERK, JNK1, and other kinases.1 SB 239063 has been shown to reduce inflammatory cytokine production in lipopolysaccharide-stimulated human peripheral blood monocytes (IC50s = 0.12 and 0.35 µM, respectively for IL-1 and TNF-α) and is neuroprotective following oral administration in a rat model of cerebral focal ischemia.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Underwood, D.C., Osborn, R.R., Kotzer, C.J., et al. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. J. Pharmacol. Exp. Ther. 293(1), 281-288 (2000).

    2. Barone, F.C., Irving, E.A., Ray, A.M., et al. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. J. Pharmacol. Exp. Ther. 296(2), 312-321 (2001).