An inducer of PDX1 expression
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BRD7552

Item No. 19143

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-bis(N-1,3-benzodioxol-5-ylcarbamate), 4-[N-[4-(ethoxycarbonyl)phenyl]carbamate], methyl, α-D-glucopyranoside
CAS Number
1137359-47-7
Molecular Formula
C33H33N3O15
Formula Weight
711.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:5): 0.2 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
252 nm
SMILES
O=C(O[C@H]1[C@H](OC(NC2=CC=C(C=C2)C(OCC)=O)=O)[C@H](O[C@H](OC)[C@@H]1OC(NC3=CC=C4C(OCO4)=C3)=O)CO)NC5=CC=C6C(OCO6)=C5
InChi Code
InChI=1S/C33H33N3O15/c1-3-43-29(38)17-4-6-18(7-5-17)34-31(39)49-26-25(14-37)48-30(42-2)28(51-33(41)36-20-9-11-22-24(13-20)47-16-45-22)27(26)50-32(40)35-19-8-10-21-23(12-19)46-15-44-21/h4-13,25-28,30,37H,3,14-16H2,1-2H3,(H,34,39)(H,35,40)(H,36,41)/t25
InChi Key
AAOLIMLEFKWKOY-IXMSMLDRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $178

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    10 mg

    $268

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    25 mg

    $587

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function.1 BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as PDX1 protein levels, in PANC-1 cells. It also increases acetylation of histone H3 and trimethylation of H3K4 and H3K9.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yuan, Y., Hartland, K., Boxkovic, Z., et al. A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem. Biol. 20(12), 1513-1522 (2013).