An orexin 1 receptor antagonist
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SB-334867

Item No. 19145

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-urea
CAS Number
792173-99-0
Molecular Formula
C17H13N5O2
Formula Weight
319.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 10 mM
λmax
242, 316 nm
SMILES
O=C(NC1=CC=C(N=C(C)O2)C2=C1)NC3=C4C(C=CC=N4)=NC=C3
InChi Code
InChI=1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23)
InChi Key
AKMNUCBQGHFICM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $83

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    10 mg

    $152

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    25 mg

    $345

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    Product Description

    SB-334867 is an antagonist of the orexin 1 receptor (OX1R; KB = 39.8 nM) that is selective for OX1R over OX2R (KB = 1,995.3 nM).1 It reduces food intake and increases resting duration in rats, as well as inhibits orexin-A-induced increases in food intake, when administered at a dose of 30 mg/kg.2 SB-334867 (10 mg/kg) inhibits orexin-A-induced increases in grooming time in rats.1 It increases the seizure threshold in both the maximal electroshock seizure threshold (MEST) and 6 Hz psychomotor seizure test in mice when administered at doses of 30 and 3 mg/kg, respectively.3 Intracerebroventricular administration of SB-334867 (0.5-50 nmol) reduces morphine-induced analgesia in the formalin test in rats.4 SB-334867 (1.5 to 6 μg, intra-dentate gyrus injection) also reduces acquisition and consolidation of spatial memory in the Morris water maze in rats.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Duxon, M.S., Stretton, J., Starr, K., et al. Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement. Psychopharmacol. (Berl) 153(2), 203-209 (2001).

    2. Rodgers, R.J., Halford, J.C.G., Nones de Souza, R.L., et al. SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. Eur. J. Neurosci. 13(7), 1444-1452 (2001).

    3. Socała, K., Szuster-Ciesielska, A., and Wlaź, P. SB 334867, a selective orexin receptor type 1 antagonist, elevates seizure threshold in mice. Life Sci. 150, 81-88 (2016).

    4. Azhdari-Zarmehri, H., Esmaeili, M.H., Sofiabadi, M., et al. Orexin receptor type-1 antagonist SB-334867 decreases morphine-induced antinociceptive effect in formalin test. Pharmacol. Biochem. Behav. 112, 64-70 (2013).

    5. Akbari, E., Naghdi, N., and Motamedi, F. The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze. Peptides 28(3), 650-656 (2007).