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BGJ398

Item № 19157
CAS № 872511-34-7
Purity ≥98%
product image
                (CAS 872511-34-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $49.00 0.00
     5 mg $98.00 0.00
     10 mg $157.00 0.00
     25 mg $257.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.

Description
Synonyms
  • Infigratinib
  • ​NVP-BGJ398

BGJ398 is an orally available inhibitor of human FGFRs (IC50s = 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively).1,2 It inhibits FGFR4 and VEGFR2 with IC50 values of 60 and 180 nM, respectively, and displays comparatively little activity towards Abl, Fyn, Kit, Lck, Lyn, and Yes (IC50s = 0.3-2.5 µM).1 BGJ398 has been shown to suppress proliferation of cancer cells with wild-type FGFR3 overexpression (IC50s = 5, 30, 32, and 15 nM, for RT112, RT4, SW780, and JMSU1 cells, respectively).1 In an RT112 bladder cancer xenograft mouse model overexpressing wild-type FGFR3, BGJ398 inhibited tumor growth after oral administration of 10-30 mg/kg.1

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Technical Information
Formal Name
N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-urea
CAS Number
872511-34-7
Synonyms
  • Infigratinib
  • ​NVP-BGJ398
Molecular Formula
C26H31Cl2N7O3
Formula Weight
560.5
Purity
≥98%
Formulation
A crystalline solid
λmax
231 nm
SMILES
COC1=C(Cl)C(NC(N(C)C2=CC(NC3=CC=C(N4CCN(CC)CC4)C=C3)=NC=N2)=O)=C(Cl)C(OC)=C1
InChI Code
InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
InChI Key
QADPYRIHXKWUSV-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Guagnano, V., Furet, P., Spanka, C., et al. Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase Journal of Medicinal Chemistry 54(20), 7066-7083 (2011).

2. Hagel, M., Miduturu, C., Sheets, M., et al. First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway Cancer Discov. 5(4), 424-437 (2015).

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