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MK-5108

Item № 19167
CAS № 1010085-13-8
Purity ≥95%
product image
                (CAS 1010085-13-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $45.00 0.00
     5 mg $203.00 0.00
     10 mg $360.00 0.00

Pricing updated 2019-04-24. Prices are subject to change without notice.

Description
Synonyms
  • VX-689

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM).1 It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types.1,2 It is effective in vivo, inhibiting the growth of xenograft tumors in mice.1

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Technical Information
Formal Name
trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-cyclohexanecarboxylic acid
CAS Number
1010085-13-8
Synonyms
  • VX-689
Molecular Formula
C22H21ClFN3O3S
Formula Weight
461.9
Purity
≥95%
Formulation
A crystalline solid
λmax
278, 310 nm
SMILES
ClC1=C(F)C(O[C@@H]2CC[C@@](CC3=CC=CC(NC4=NC=CS4)=N3)(C(O)=O)CC2)=CC=C1
InChI Code
InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)/t15-,22-
InChI Key
LCVIRAZGMYMNNT-VVONHTQRSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Harrington, E.A., Bebbington, D., Moore, J., et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo Nature Medicine 10(3), 262-267 (2004).

2. Shimmoura, T., Hasako, S., Nakatsuru, Y., et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel Molecular Cancer Therapeutics 9(1), 157-166 (2010).

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