Pricing updated 2019-04-24. Prices are subject to change without notice.
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM).1 It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types.1,2 It is effective in vivo, inhibiting the growth of xenograft tumors in mice.1
Warning - this product is not for human or veterinary use.
View the Cayman Structure Database for chemical structure definitions for many Cayman products
Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.
Harrington, E.A., Bebbington, D., Moore, J., et al. VX-
Shimmoura, T., Hasako, S., Nakatsuru, Y., et al. MK-