Pricing updated 2019-06-15. Prices are subject to change without notice.
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM).1 It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types.1,2 It is effective in vivo, inhibiting the growth of xenograft tumors in mice.1
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Harrington, E.A., Bebbington, D., Moore, J., et al. VX-
Shimmoura, T., Hasako, S., Nakatsuru, Y., et al. MK-