Pricing updated 2019-07-18. Prices are subject to change without notice.
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.1 BMS-265246 is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin E (IC50s = 6 and 9 nM, respectively).2 It less potently inhibits Cdk4/cyclin D (IC50 = 0.23 μM).2 BMS-265246 blocks the cycling of HCT116 cells (EC50 = 0.29-0.49 µM), resulting in cell cycle arrest in G2 phase.3
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Bettayeb, K., Baunbaek, D., Delehouze, C., et al. CDK inhibitors roscovitine and CR8 trigger Mcl-
Misra, R.N., Xiao, H., Rawlins, D.B., et al. 1H-
Sutherland, J.J., Low, J., Blosser, W., et al. A robust high-