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BMS-265246

Item № 19168
CAS № 582315-72-8
Purity ≥95%
product image
                (CAS 582315-72-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $49.00 0.00
     5 mg $221.00 0.00

Pricing updated 2019-04-24. Prices are subject to change without notice.

Description

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.1 BMS-265246 is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin E (IC50s = 6 and 9 nM, respectively).2 It less potently inhibits Cdk4/cyclin D (IC50 = 0.23 μM).2 BMS-265246 blocks the cycling of HCT116 cells (EC50 = 0.29-0.49 µM), resulting in cell cycle arrest in G2 phase.3

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Technical Information
Formal Name
(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone
CAS Number
582315-72-8
Molecular Formula
C18H17F2N3O2
Formula Weight
345.3
Purity
≥95%
Formulation
A crystalline solid
λmax
210, 245, 291 nm
SMILES
CC1=CC(F)=C(C(C2=C(OCCCC)C(C=NN3)=C3N=C2)=O)C(F)=C1
InChI Code
InChI=1S/C18H17F2N3O2/c1-3-4-5-25-17-11(8-21-18-12(17)9-22-23-18)16(24)15-13(19)6-10(2)7-14(15)20/h6-9H,3-5H2,1-2H3,(H,21,22,23)
InChI Key
SCFMWQIQBVZOQR-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Bettayeb, K., Baunbaek, D., Delehouze, C., et al. CDK inhibitors roscovitine and CR8 trigger Mcl-I down-regulation and apoptotic cell death in neuroblastoma cells Genes Cancer 1(4), 369-380 (2010).

2. Misra, R.N., Xiao, H., Rawlins, D.B., et al. 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: Highly potent 2,6-Difluorophenacyl analogues Bioorganic & Medicinal Chemistry Letters 13(14), 2405-2408 (2003).

3. Sutherland, J.J., Low, J., Blosser, W., et al. A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators Molecular Cancer Therapeutics 10(2), 242-254 (2011).

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