A selective pan-Aurora kinase inhibitor
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AMG 900

Item No. 19176

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine
CAS Number
945595-80-2
Molecular Formula
C28H21N7OS
Formula Weight
503.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 15 mg/ml
λmax
212, 325 nm
SMILES
NC1=NC=CC(C2=C(OC3=CC=C(NC4=C(C=CC=C5)C5=C(C6=CC(C)=CS6)N=N4)C=C3)N=CC=C2)=N1
InChi Code
InChI=1S/C28H21N7OS/c1-17-15-24(37-16-17)25-20-5-2-3-6-21(20)26(35-34-25)32-18-8-10-19(11-9-18)36-27-22(7-4-13-30-27)23-12-14-31-28(29)33-23/h2-16H,1H3,(H,32,35)(H2,29,31,33)
InChi Key
IVUGFMLRJOCGAS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $382

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    25 mg

    $856

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    Product Description

    AMG 900 is an orally bioavailable, selective Aurora kinase inhibitor with IC50 values of 5, 4, and 1 nM for Aurora A, B, and C, respectively.1 It is greater than 10-fold selective for Aurora kinases over p38α, TYK2, JNK2, Met, and Tie2 (IC50s = 53, 220, 520, 550, and 650 nM, respectively).1 At 2-3 nM, AMG 900 has been shown to inhibit the proliferation of 26 different tumor cell lines in vitro, including cell lines resistant to either the antimitotic agent paclitaxel (Item No. 10461) or to other Aurora kinase inhibitors.1 Furthermore, AMG 900 is reported to be broadly active in multiple xenograft models, including three multidrug-resistant xenograft models, representing five tumor types.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Payton, M., Bush, T.L., Chung, G., et al. Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 70(23), 9846-9854 (2010).

    Product Citations

    Li, T., Huang, T., Du, M., et al. Phosphorylation and chromatin tethering prevent cGAS activation during mitosis. Science (2021).