A selective, cell-permeable inhibitor of MLCK
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MLCK Inhibitor Peptide 18

Item No. 19181

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl-L-lysinamide
CAS Number
224579-74-2
Synonyms
  • Myosin Light Chain Kinase Inhibitor Peptide 18
Molecular Formula
C60H105N23O11
Formula Weight
1324.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mLDMSO: 5 mg/mLEthanol: 12 mg/mLPBS (pH 7.2): 5 mg/mL
λmax
226, 278 nm
SMILES
O=C([C@H](CC1=CC=C(C=C1)O)NC([C@@H](NC([C@H](CC2=CC=C(C=C2)O)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CCCCN)=O)CCCCN)=O)=O)CCCCN)=O)N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N
InChi Code
InChI=1S/C60H105N23O11/c61-27-5-1-13-41(49(66)86)76-51(88)45(17-10-32-74-59(69)70)79-53(90)46(18-11-33-75-60(71)72)81-57(94)48(35-37-21-25-39(85)26-22-37)83-55(92)44(16-4-8-30-64)80-56(93)47(34-36-19-23-38(84)24-20-36)82-54(91)43(15-3-7-29-63)78-52(8
InChi Key
JPOKAKNGULMYHZ-UILVTTEASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $36

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    1 mg

    $68

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    5 mg

    $236

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    10 mg

    $436

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    Product Description

    MLCK inhibitor peptide 18 is a cell-permeable inhibitor of myosin light chain kinase (MLCK; IC50 = 50 nM) with 4,000-fold selectivity for MLCK over CaM kinase II and PKA.1,2 It prevents defects in transepithelial barrier resistance induced by bacteria or TNF-α plus IFN-γ.2 MLCK inhibitor peptide 18 prevents sperm chromatin-induced cortical reorganization in mouse oocytes and decreases phagocytosis of C3bi-opsonized and non-opsonized myelin by primary mouse microglia.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lukas, T.J., Mirzoeva, S., Slomczynska, U., et al. Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J. Med. Chem. 42(5), 910-919 (1999).

    2. Zolotarevsky, Y., Hecht, G., Koutsouris, A., et al. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123(1), 163-172 (2002).

    3. Deng, M., Williams, C.J., and Schultz, R.M. Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarity. Dev. Biol. 278(2), 358-366 (2005).

    4. Gitik, M., Reichert, F., and Rotschenker, S. Cytoskeleton plays a dual role of activation and inhibition in myelin and zymosan phagocytosis by microglia. The FASEB Journal 24(7), 2211-2221 (2010).