A selective, cell-permeable inhibitor of MLCK
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MLCK Inhibitor Peptide 18

Item No. 19181

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl-L-lysinamide
CAS Number
224579-74-2
Synonyms
  • Myosin Light Chain Kinase Inhibitor Peptide 18
Molecular Formula
C60H105N23O11
Formula Weight
1324.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mLDMSO: 5 mg/mLEthanol: 12 mg/mLPBS (pH 7.2): 5 mg/mL
λmax
226, 278 nm
SMILES
O=C([C@H](CC1=CC=C(C=C1)O)NC([C@@H](NC([C@H](CC2=CC=C(C=C2)O)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CCCCN)=O)CCCCN)=O)=O)CCCCN)=O)N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N
InChi Code
InChI=1S/C60H105N23O11/c61-27-5-1-13-41(49(66)86)76-51(88)45(17-10-32-74-59(69)70)79-53(90)46(18-11-33-75-60(71)72)81-57(94)48(35-37-21-25-39(85)26-22-37)83-55(92)44(16-4-8-30-64)80-56(93)47(34-36-19-23-38(84)24-20-36)82-54(91)43(15-3-7-29-63)78-52(8
InChi Key
JPOKAKNGULMYHZ-UILVTTEASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $36

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    1 mg

    $68

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    5 mg

    $236

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    10 mg

    $436

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    Product Description

    MLCK inhibitor peptide 18 is a cell-permeable inhibitor of myosin light chain kinase (MLCK; IC50 = 50 nM) with 4,000-fold selectivity for MLCK over CaM kinase II and PKA.1,2 It prevents defects in transepithelial barrier resistance induced by bacteria or TNF-α plus IFN-γ.2 MLCK inhibitor peptide 18 prevents sperm chromatin-induced cortical reorganization in mouse oocytes and decreases phagocytosis of C3bi-opsonized and non-opsonized myelin by primary mouse microglia.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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