An aldose reductase 2 inhibitor
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Statil

Item No. 19189

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid
CAS Number
72702-95-5
Synonyms
  • ICI 128436
  • MK-538
  • Ponalrestat
Molecular Formula
C17H12BrFN2O3
Formula Weight
391.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mLDMSO: 2 mg/mLEthanol: 2 mg/mLPBS (pH 7.2): 0.2 mg/mL
λmax
212, 256, 288 nm
SMILES
BrC1=CC=C(CN2C(C(C=CC=C3)=C3C(CC(O)=O)=N2)=O)C(F)=C1
InChi Code
InChI=1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)
InChi Key
LKBFFDOJUKLQNY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 µM, respectively.1 Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats.2 Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ward, W.H.J., Sennitt, C.M., Ross, H., et al. Ponalrestat: A potent and specific inhibitor of aldose reductase. Biochem. Pharmacol. 39(2), 337-346 (1990).

    2. Otter, D.J., and Chess-Williams, R. The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats. Br. J. Pharmacol. 113(2), 576-580 (1994).

    3. Michaud, A., Lacroix-Pépin, N., Pelletier, M., et al. Prostaglandin (PG) F2 alpha synthesis in human subcutaneous and omental adipose tissue: Modulation by inflammatory cytokines and role of the human aldose reductase AKR1B. PLoS One 9(3), (2014).