A precursor for various antibiotic and anticancer agents
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2-hydroxy-6-Methylbenzoic Acid

Item No. 19199

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-6-methyl-benzoic acid
CAS Number
567-61-3
Synonyms
  • 2,6-Cresotic Acid
  • 6-Methylsalicylic Acid
  • 6-MSA
  • NSC 403256
  • 6-hydroxy-o-Toluic Acid
Molecular Formula
C8H8O3
Formula Weight
152.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 5 mg/ml
λmax
209, 242, 308 nm
SMILES
CC1=C(C(O)=O)C(O)=CC=C1
InChi Code
InChI=1S/C8H8O3/c1-5-3-2-4-6(9)7(5)8(10)11/h2-4,9H,1H3,(H,10,11)
InChi Key
HCJMNOSIAGSZBM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $69

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    5 g

    $297

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    10 g

    $525

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    Product Description

    2-hydroxy-6-Methylbenzoic acid is a constituent of G. anandria, a well-known traditional Chinese medicinal herb, and also produced in various fungi, including P. patulum, where it is a precursor to the toxin patulin (Item No. 11346).1,2 This polyketide is a key structural moiety for many different antibiotic and anticancer agents, including chlorothricin (Item No. 15501), maduropeptin, neocarzinostatin, and terreic acid.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. He, F., Wang, M., Gao, M., et al. Chemical composition and biological activities of Gerbera anandria. Molecules 19(4), 4046-4057 (2014).

    2. Parascandolo, J.S., Havermann, J., Potter, H.K., et al. Insights into 6-methylsalicylic acid bio-assembly by using chemical probes. Angew. Chem. Int. Ed. Engl. 55(10), 3463-3467 (2016).

    3. Guo, C.J., Sun, W.W., Bruno, K.S., et al. Molecular genetic characterization of terreic acid pathway in Aspergillus terreus. Org. Lett. 16(20), 5250-5253 (2014).