A selective inhibitor of MMP-2, -9, and -14
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ND-336

Item No. 19207

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-[(2-thiiranylmethyl)sulfonyl]phenoxy]-benzenemethanamine, monohydrochloride
CAS Number
1807453-83-3
Molecular Formula
C16H17NO3S2 • HCl
Formula Weight
371.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
λmax
245, 333 nm
SMILES
NCC(C=C1)=CC=C1OC2=CC=C(S(CC3SC3)(=O)=O)C=C2.Cl
InChi Code
InChI=1S/C16H17NO3S2.ClH/c17-9-12-1-3-13(4-2-12)20-14-5-7-16(8-6-14)22(18,19)11-15-10-21-15;/h1-8,15H,9-11,17H2;1H
InChi Key
DRGIZFGSEKSFIC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $49

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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    ND-336 is a selective inhibitor of the gelatinases matrix metalloproteinase-2 (MMP-2) and MMP-9, as well as MMP-14 (Kis = 85, 150, and 120 nM, respectively).1 It has minimal effect on other MMPs. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gao, M., Nguyen, T.T., Suckow, M.A., et al. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proc. Natl. Acad. Sci. USA 112(49), (2015).