A histamine H1 antagonist
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Metabolite(s)
345181-(4-Chlorobenzhydryl)piperazine
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Chlorcyclizine (hydrochloride)

Item No. 19239

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-chlorophenyl)phenylmethyl]-4-methyl-piperazine, monohydrochloride
CAS Number
14362-31-3
Synonyms
  • NSC 169496
Molecular Formula
C18H21ClN2 • HCl
Formula Weight
337.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
230 nm
SMILES
CN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.Cl
InChi Code
InChI=1S/C18H21ClN2.ClH/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16;/h2-10,18H,11-14H2,1H3;1H
InChi Key
MSIJLVMSKDXAQN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $69

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    Cayman Chemical
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    Product Description

    Chlorcyclizine is a phenylpiperazine that acts as a histamine H1 receptor antagonist (Ki = 9 nM).1 It has also been shown to be effective against hepatitis C virus (HCV; EC50 = 44 nM in vitro), preventing viral entry into host cells.2 In chimeric mice engrafted with primary human hepatocytes, 10-50 mg/kg chlorcyclizine significantly inhibited infection of HCV genotypes 1b and 2a.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tran, V.T., Chang, R.S.L., and Snyder, S.H. Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. Proc. Natl. Acad. Sci. USA 75(12), 6290-6294 (1978).

    2. He, S., Xiao, J., Dulcey, A.E., et al. Discovery, optimization, and characterization of novel chlorcyclizine derivatives for the treatment of hepatitis C virus infection. J. Med. Chem. 59(3), 841-853 (2016).