An Analytical Reference Material
Features
  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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U-50488 (hydrochloride)

Item No. 19363

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-3,4-dichloro-N-methyl-N-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide, monohydrochloride
CAS Number
67197-96-0
Molecular Formula
C19H26Cl2N2O • HCl
Formula Weight
405.8
Purity
≥98%
Formulation
A neat solid
SMILES
ClC1=C(Cl)C=CC(CC(N(C)[C@@H]2CCCC[C@H]2N3CCCC3)=O)=C1.Cl
InChi Code
InChI=1S/C19H26Cl2N2O.ClH/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H/t17-,18-;/m1./s1
InChi Key
KGMMGVIYOHGOKQ-JAXOOIEVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    U-50488 (hydrochloride) (Item No. 19363) is an analytical reference material categorized as an opioid.1 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Von Voigtlander, P.F., and Lewis, R.A. U-50,488, a selective kappa opioid agonist: Comparison to other reputed kappa agonists. Prog. Neurpsychopharmacol. Biol. Psychiatry 6(4-6), 467-470 (1982).

    Product Citations

    Otte, L., Wilde, M., Auwärter, V., et al. Investigation of the μ- and κ-opioid receptor activation by eight new synthetic opioids using the [35S]-GTPγS assay: U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520, and U-48800. Drug Test. Anal. 14(7), 1187-1199 (2022).

    Berardinelli, D., Taoussi, O., Ovat, D.Y., et al. Human metabolism and pharmacological profiling of protonitazepyne and metonitazepyne, two highly potent nitazenes: prediction of main metabolite activity based on µ-opioid receptor docking simulations. Arch. Toxicol. (2025).