We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

Bavachinin

Item № 19376
CAS № 19879-30-2
Purity ≥98%
product image
                (CAS 19879-30-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $25.00 0.00
     5 mg $94.00 0.00
     10 mg $175.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • 7-O-Methylbavachin

Bavachinin is a natural flavanone first isolated from seeds of P. corylifolia. It is a pan-PPAR agonist (EC50s = 4.0, 8.1, and 0.74 µM for PPARα, β/δ, and γ, respectively).1 Bavachinin has synergistic effects when combined with thiazolidinediones or fibrates. It lowers glucose and triacylglycerol levels in db/db mice without inducing weight gain or hepatotoxicity.1 Bavachinin also has actions that block allergic inflammation, angiogenesis, and Aβ42 aggregation in vitro.2,3,4

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
(2S)-2,3-dihydro-2-(4-hydroxyphenyl)-7-methoxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
CAS Number
19879-30-2
Synonyms
  • 7-O-Methylbavachin
Molecular Formula
C21H22O4
Formula Weight
338.4
Purity
≥98%
Formulation
A crystalline solid
λmax
219, 233, 273, 320 nm
SMILES
O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=C1C=C(C/C=C(C)/C)C(OC)=C3
InChI Code
InChI=1S/C21H22O4/c1-13(2)4-5-15-10-17-18(23)11-20(14-6-8-16(22)9-7-14)25-21(17)12-19(15)24-3/h4,6-10,12,20,22H,5,11H2,1-3H3/t20-/m0/s1
InChI Key
VOCGSQHKPZSIKB-FQEVSTJZSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Feng, L., Luo, H., Xu, Z., et al. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-γ and PPAR-α agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice Diabetologia 59(6), 1276-1286 (2016).

2. Chen, X., Yang, Y., and Zhang, Y. Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro FEBS Lett. 587(18), 29350-29355 (2013).

3. Chen, X., Wen, T., Wei, J., et al. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs Cell. Mol. Immunol. 10(6), 497-505 (2013).

4. Nepal, M., Choi, H.J., Choi, B.-Y., et al. Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor- Eur. J. Pharmacol. 691(1-3), 28-37 (2012).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640