Bavachinin

Bavachinin is a natural flavanone first isolated from seeds of P. corylifolia. It is a pan-PPAR agonist (EC₅₀s = 4.0, 8.1, and 0.74 µM for PPARα, β/δ, and γ, respectively).¹ Bavachinin has synergistic effects when combined with thiazolidinediones or fibrates. It lowers glucose and triacylglycerol levels in db/db mice without inducing weight gain or hepatotoxicity.¹ Bavachinin also has actions that block allergic inflammation, angiogenesis, and Aβ42 aggregation in vitro.^2,3,4

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1. Feng, L., Luo, H., Xu, Z., et al. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-γ and PPAR-α agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice. Diabetologia 59(6), 1276-1286 (2016).

2. Chen, X., Yang, Y., and Zhang, Y. Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro. FEBS Lett. 587(18), 29350-29355 (2013).

3. Chen, X., Wen, T., Wei, J., et al. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs. Cell. Mol. Immunol. 10(6), 497-505 (2013).

4. Nepal, M., Choi, H.J., Choi, B.-Y., et al. Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α. Eur. J. Pharmacol. 691(1-3), 28-37 (2012).