An irreversible inhibitor of stearoyl-CoA desaturase
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SW203668 (trifluoroacetate salt)

Item No. 19379

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide, trifluoroacetate salt
CAS Number
2117405-48-6
Molecular Formula
C22H19N3O2S • CF3COOH
Formula Weight
503.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
316 nm
SMILES
COC1=CC=C2C(SC(NC(C3=CC=C(C(N)C4=CC=CC=C4)C=C3)=O)=N2)=C1.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C22H19N3O2S.C2HF3O2/c1-27-17-11-12-18-19(13-17)28-22(24-18)25-21(26)16-9-7-15(8-10-16)20(23)14-5-3-2-4-6-14;3-2(4,5)1(6)7/h2-13,20H,23H2,1H3,(H,24,25,26);(H,6,7)
InChi Key
SIUPHFAIFLEFIT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    Cayman Chemical
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    Product Description

    SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM).1 It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Theodoropoulos, P.C., Gonzales, S.S., Winterton, S.E., et al. Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Nat. Chem. Biol. 12(4), 218-225 (2016).