An inhibitor of FAHFA hydrolases
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JJH260

Item No. 19384

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(4-chlorophenyl)ethyl]-1-piperidinecarboxylic acid, 7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-yl ester
CAS Number
1831135-30-8
Molecular Formula
C29H34ClN5O5
Formula Weight
568.1
Purity
≥90%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/ml
λmax
220, 301 nm
SMILES
CN(C)C(C=C1)=CC=C1C(N2CCN(C(N(OC(N3CCC(CCC4=CC=C(Cl)C=C4)CC3)=O)C5=O)=O)C5C2)=O
InChi Code
InChI=1S/C29H34ClN5O5/c1-31(2)24-11-7-22(8-12-24)26(36)33-17-18-34-25(19-33)27(37)35(28(34)38)40-29(39)32-15-13-21(14-16-32)4-3-20-5-9-23(30)10-6-20/h5-12,21,25H,3-4,13-19H2,1-2H3
InChi Key
RISSJZZMOJQTIN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

    $253

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    5 mg

    $1,191

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    Product Description

    JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA (Item No. 17037) with an IC50 value of 0.57 µM.1 JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 µM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2.1 JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Parsons, W.H., Kolar, M.J., Kamat, S.S., et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat. Chem. Biol. 12(5), 367-372 (2016).