An ATP-dependent potassium channel blocker
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Labeled Version(s)
26104Repaglinide-d5
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Repaglinide

Item No. 19387

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]-benzoic acid
CAS Number
135062-02-1
Molecular Formula
C27H36N2O4
Formula Weight
452.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mlEthanol: 25 mg/ml
λmax
243, 293 nm
SMILES
CC(C[C@@H](C1=CC=CC=C1N2CCCCC2)NC(CC3=CC(OCC)=C(C=C3)C(O)=O)=O)C
InChi Code
InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1
InChi Key
FAEKWTJYAYMJKF-QHCPKHFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $108

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    250 mg

    $256

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    500 mg

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    1 g

    $589

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Repaglinide is a metaglitinide antidiabetic agent that blocks ATP-dependent potassium (Kir6) channels in pancreatic β-cells (Kd = 0.42 nM for the sulphonylurea receptor SUR1 when co-expressed with Kir6.2).1 In vivo, repaglinide lowers blood glucose in fasted rats and dogs (ED50s = 10 and 28.3 μg/kg, respectively).2 Formulations containing repaglinide have been used to control blood sugar levels in patients with type 2 diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hansen, A.M.K., Hansen, J.B., Carr, R.D., et al. Kir6.2-dependent high-affinity repaglinide binding to β-cell KATP channels. Br. J. Pharmacol. 144(4), 551-557 (2005).

    2. Mark, M., and Grell, W. Hypoglycaemic effects of the novel antidiabetic agent repaglinide in rats and dogs. Br. J. Pharmacol. 121(8), 1597-1604 (1997).