A mycotoxic cytochalasin
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Chaetoglobosin A

Item No. 19405

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-4,7,14,14a,15,15a,16a,16b-octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-3H-cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione
CAS Number
50335-03-0
Molecular Formula
C32H36N2O5
Formula Weight
528.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
C/C([C@@H](O)C(/C=C/C1=O)=O)=C/[C@@H](C)C/C=C/[C@]2([H])[C@]1(C(N[C@H]3CC4=CNC5=C4C=CC=C5)=O)[C@@]3([H])[C@H](C)[C@]6(C)[C@H]2O6
InChi Code
InChI=1S/C32H36N2O5/c1-17-8-7-10-22-29-31(4,39-29)19(3)27-24(15-20-16-33-23-11-6-5-9-21(20)23)34-30(38)32(22,27)26(36)13-12-25(35)28(37)18(2)14-17/h5-7,9-14,16-17,19,22,24,27-29,33,37H,8,15H2,1-4H3,(H,34,38)/b10-7+,13-12+,18-14-/t17-,19-,22-,24-,27-,28+,29-,31+,32+/m0/s1
InChi Key
OUMWCYMRLMEZJH-HSXMBTRQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Chaetoglobosin A is a mycotoxic cytochalasin that was first isolated from the marine-derived endophytic fungus C. globosum.1 It targets filamentous actin and demonstrates antibacterial and nematicidal effects as well as induces apoptosis in cancer cell lines.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cui, C.M., Li, X.M., Li, C.S., et al. Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. J. Nat. Prod. 73(4), 729-733 (2010).

    2. Yahara, I., Harada, F., Sekita, S., et al. Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro. J. Cell Biol. 92(1), 69-78 (1982).

    3. Hu, Y., Zhang, W., Zhang, P., et al. Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognita. J. Agric. Food Chem. 61(1), 41-46 (2013).

    4. Knudsen, P.B., Hanna, B., Ohl, S., et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia 28(6), 1289-1298 (2014).